Progression from ileal disease to pancolitis within 5 years

What is known

• Crohn's disease location (montreal L-classification) is relatively stable over time, and what location change does occur in the retrieved pediatric cohort was predominantly extension via increasing ileal involvement rather than acquisition of new colonic/pancolonic disease ¹.

What is unknown / caveats

• The retrieved corpus does not report a rate of progression from isolated ileal crohn's to pancolitis at five years.

References

1. Van Limbergen J, Russell RK, Drummond HE, Aldhous MC, Round NK, Nimmo ER, Smith L, Gillett PM, McGrogan P, Weaver LT, Bisset WM, Mahdi G, Arnott ID, Satsangi J, Wilson DC. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology. 2008;135(4):1114-22. PMID: 18725221.

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Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct.